Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture

Objective: Cancer is the most common cause of death after cardiovascular diseases. Cisplatin used in types cancer produces neurotoxicity. In this study, we aimed to investigate effects pomegranate peel extract (1) different doses, as potent antioxidants, on prevention neurotoxicity due cisplatin, which frequently treatment. Methods: our newborn rat cortex was used. 2 hours following application PPE at 200, 300 and 400 mg/mL, established by applying cisplatin 50 100 µM concentrations. Results: decreased cell viability increasing while showed best neuroprotective effect high doses. Increased total oxidant capacity toxicity significantly improved PPE4. The antioxidant group improvement with administration At same time, increased TNF-α mRNA expression reduced caspase 3 (CAS 3) 9 9) Conclusion: These results indicated that could inhibit cisplatin-induced neurotoxicity, these may be related anti-apoptotic antioxidants activities.